DESIGN, SYNTHESIS AND IN VITRO ANTITUBERCULAR SCREENING OF NOVEL TRISUBSTITUTED -3A, 4-DIHYDRO [1, 2, 3] TRIAZOLO [1, 5-A] QUINAZOLIN-5(3H)-ONE DERIVATIVES

Abstract: Unique trisubstituted-3a, 4-dihydro [1, 2, 3] compounds dichloromethyl [1, 5-a] quinazolin-5(3H)-one derivatives were synthesised and analysed using 1HNMR, C13NMR, and MASS for all of the compound titles. We used the Microplate Alamar Blue Assay to examine the compounds' invitro antitubercular activity. We used rifampicin, isoniazid, and ethambutol as reference standards to estimate the MIC values of the most effective inhibitors for MTB, H37Rv, and H37Ra cultures. When compared to the reference standards, S04 and S09, out of all the synthesised compounds, demonstrate excellent invitro anti tubercular activity. So, S04 and S09 can be the starting point for future studies.