POLYURETHANE NANOPARTICLES AND INJECTABLE HYDROGELS: A SYNERGISTIC APPROACH TO ENHANCED DRUG DELIVERY SYSTEMS

Abstract: This review article provides a critical account of the recent development in the incorporation of polyurethane nanoparticles with injectable hydrogels for drug delivery applications. The primary purpose of the review is to identify the recent developments, their working principles and various uses of such new material that will help to enhance therapeutic efficacy and accuracy. These polyurethane nanoparticles have good biocompatibility, mechanical strength and broad applicability for drug delivery. At the same time, the injectable hydrogel provides possibilities for dynamic in situ gelation, accurate controlled release, and target delivery. The interaction of these two technologies is such that there is a significant improvement in the efficiency of drug loading, targeting delivery and sustaining release characteristics. Some of the major conclusions drawn from the current literature reveal that the dispersion of polyurethane nanoparticles with the hydrogel matrices significantly enhances the drug delivery effectiveness. This is basically because of enhanced nanoparticle stability, well-regulated release profiles and sensitivity to physiological signals. These are relatively complicated structures that need enhanced characterization methods, from electron microscopy to spectroscopy, as well as extensive biological analysis. The current issues regarding the design and clinical application of these hybrid systems and potential areas of future research will be also discussed in the review. Therefore, the concepts of polyurethane nanoparticles incorporated with injectable hydrogels are promising approaches in the future drug delivery system. This approach will also help to reduce all the limitations of the traditional methods of delivery and open new opportunities for the individualization of treatment and targeted therapy. More work has to be done on these areas for scalable processes and regulations to capture the full clinical potential of this new class of materials.